ED treatment should be standardized

According to WHO guidelines, FDE5 inhibitors are first-line treatment of ED drugs, but despite the fast FDE5 inhibitor effects, side effects, there are still many patients refuse to use FDE5 inhibitors, because of the high price of such products, time is short.PDE5 inhibitor for the treatment of a new generation of ED provides a new therapeutic approach.

Currently there are three PDE5 inhibitors: sildenafil, vardenafil, tadalafil.Pharmacokinetics showed that the highest concentration of sildenafil up to 560ng/ml, the highest for the three drugs; sildenafil and vardenafil as 4 hours after taking the drug can be excreted, there is expected taken as early as possible before having sex (0.5 to 4 hours may be); Sildenafil and vardenafil are affected by the high-fat diet to slow absorption, but bioavailability varies widely between the two were 40% and 15%, indicating that the bioavailability of vardenafil low; tadalafil role in the body to maintain up to 24 ~ 36 hours, excreted slowly, and can accumulate in the body for long-acting preparations.

From the perspective of pharmacokinetics, bioavailability may result difficult to predict the low rate of drug dosage required, the effective blood concentration variation and increased risk of drug interactions.Thus, while sildenafil and tadalafil is more appropriate for ED patients, but because of the short efficacy of sildenafil, ED is not conducive to healing.

64% of middle-aged ED patients have chronic diseases such as cardiovascular disease, diabetes and so on.In the United States of MONMENTUS study, through a multi-center study in the ED evaluation of tadalafil in men with multiple complications, the efficacy and safety of the 155 cases of patients suffering from complications of treatment for 12 weeks and found taking tadalafil most common adverse events were headache (5.9%), hot flashes (3.9%), nasal congestion (3.2%), only 3% of patients discontinued because of adverse events and no patients taking tadalafil as The complications of the original impact, or increase the previous complications.