"Viagra" and its "brothers"

"Viagra" and its "brothers"

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Oral drug in treatment of male erectile dysfunction (ED), is the therapy of choice for today's in this area. This oral drug therapy of popularity, mainly in 1998 by the United States food and Drug Administration (FDA) final approval of viagra is set off, so we start with viagra said.

 

"Viagra" viagra

 

Wan Aike in the country was once called "viagra". The mechanism is through a series of biochemical reactions, corpus cavernosum smooth muscle tissue in the body to relax, so the penis is a large number of patients and erectile dysfunction. Originally, subjected to sexual stimulation, they release large amounts of nitric oxide in human body, when nitric oxide into the corpus cavernosum smooth muscle cells, with the help of certain enzymes, produce many cyclic Guanosine monophosphate (CGMP), Guanosine monophosphate will role play to relaxation of smooth muscle of the penis and penile erectile dysfunction patients. This shows that the erectile function is good or bad, depending on the number of Guanosine monophosphate, erectile dysfunction, erectile dysfunction not less. However, in the corpus cavernosum tissue, another substance called Phosphodiesterase-5 (PDA-5), would break down damage cyclic Guanosine monophosphate, thereby reducing the number of Guanosine monophosphate, clearly to the disadvantage of penile erection. Effect of viagra is exactly here, it has a block Phosphodiesterase-5 damage effectiveness of Guanosine monophosphate, ensure the intracavernous still has a sufficient number of cyclic Guanosine monophosphate, also ensures the penis erectile dysfunction.

 

September 1998-February 1999, China's 7 hospitals (including hospital where the author) on a phase � clinical trial viagra, a total of 628 patients with erectile dysfunction to participate in testing. Results show that effectively improve the erectile function of the ratio as high as 81%. Author 91 cases in the hospital for the 628 cases, improve erectile dysfunction rates as high as 100%. Prove efficacy of viagra is really justified. Furthermore, adverse reactions are minor, mostly flushing (11.4%), dizziness (7.4%), headache (3.6%), a stuffy nose (3.6%), Visual anomalies (3.8%), the vast majority of mild and transient, not to affect the situation as a whole. Million AI can just listed before and after, media has its caused by people death of reported, after carefully of review, United States food drug supervision authority (FDA) still let its continues to application, they of conclusions is: no found death causes directly and million AI can about! in other words, as long as you correct master million AI can of using range, to formal hospital with doctor prescription medication, this class accident does not occurs. Commonly used doses of 25~100 mg to 1 hour before sexual intercourse oral, last for duration of up to 4 hours, must play a role in sexual stimulation.

 

5 young man

 

After viagra and 2 kinds of Phosphodiesterase inhibitors of-5 came into being, namely, xiaili and Ai Lida, is the same room before taking their usual dose is 20 mg at a time, the former more maintain effects of 36 hours; the latter maintain time and similar to viagra.

 

In addition, there are several application in China so far:

 

Yohimbine is an α-adrenergic receptor blockers. The original, in the human body has a class of substances called α-adrenergic, corpus cavernosum smooth muscle contraction, soft penis shrink, to the disadvantage of penile erection. Α-adrenergic receptor blockers can prevent their play this role. In human penile tissue, involve Alpha-adrenergic receptors can be classified into Alpha 1 and Alpha 22, Alpha 1, 90% alpha 2 10%. Yohimbine's main role is to block alpha 2 receptors, but because of the smaller percentage of alpha 2, so promote penile erection efficacy of yohimbine is not very satisfactory, total erectile dysfunction improvement rate of 46%. Oral dose-5.4 mg 3 times daily, to more than 3 consecutive weeks until onset, no obvious side effects.

 

Phentolamine is an adrenergic receptor blocker, similar mechanisms with yohimbine, different is that it can block within the penis 90% proportion of Alpha-1 receptors, so there are efficiencies over yohimbine, can reach about 60%. Sexual life once before taking 40~80 mg at a time. After the Administration may have mild adverse reactions such as headaches, dizziness, Vertigo.

 

Trazodone is an antidepressant drug, its mechanism of erectile dysfunction is more complex, involving a substance called serotonin. Generally speaking, 5-serotonin being agreed with inhibition of physiological activity of role, no doubt to the disadvantage of penile erection. Trazodone inhibits serotonin function, erectile, effective rate can reach 50%. Each oral 50 mg, 3 times daily. Easily the most significant adverse effects are served at the beginning of sleepiness.

 

Worth a to of is, who because man body male hormone lack caused erectile dysfunction function obstacles who, can used male hormone drug treatment, now application more of is oral type 11 acid testosterone ketone (commodity name: residential special,), daily 80~L60 mg, sooner or later min 2 times oral, for improve erectile dysfunction function of effect can up 80% above, rarely has bad reaction, but suffers from prostate hyperplasia syndrome or prostate cancer of erectile dysfunction function obstacles patients bogey with.