Drugs that can cure ED

Drugs that can cure ED
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First, according to the mechanism of drug action and play the role of biological pharmaceutical effect parts, now many drugs are divided into five categories:

1 central starting the drug, a major role in the central nervous system, start the erectile dysfunction.

2 start around drugs, main role in the peripheral nervous system, leading to penile erection.

3 Central-promoting drugs, their role is to improve the environment in the central nervous system, promotion of erectile dysfunction or enhances erectile function.

4-promoting drugs around, its role is to improve partial or peripheral nervous system in the environment, promoting or enhancing penis erectile dysfunction.

5 other types, including penile erection equipment and surgery (penile prosthesis implantation of vascular reconstruction surgery) and natural medicine.

Second, the research progress on mechanism of drug action, clinicians recognize that normal erectile through psychological, physiological and biochemical effects, by Jeremy Bentham in hormones, neurotransmitters, vascular active substances and the results of intracavernous variety of synergy factor. In recent years more explicitly related to neurotransmitters and nerves, blood vessels causes the erectile mechanism of biological effects. There are three main mechanisms:

1 by intracellular cyclic nucleotides cAMP role, leading to smooth muscle relaxation.

2 by intracellular cyclic nucleotides cGMP, leading to smooth muscle relaxation.

3 by inside and outside the cell and potassium calcium regulating role of ion pumps, causing smooth muscle relaxation.

Has been identified that nitric oxide (NO) activates guanylate Cyclase, the GTP into cGMP, Central (cGMP) played its second Messenger function, leading to smooth muscle relaxation, penile erection. Prostaglandin E1 (PGE 1) and vasoactive intestinal peptide (VIP) can activate Adenylate Cyclase, the ATP into cyclic adenosine acid (cAMP) played its second Messenger function, leading to smooth muscle relaxation, penile erection. PGE and NO 1 can influence inside and outside the cell and potassium calcium pump of change, leading to smooth muscle relaxation, penile erection.

Three, mainly oral drugs

1 Awa morphine (Apomorphine) is the central starting the drug. It is morphine derivatives, belonging to the D1 dopamine receptor agonist, sexual activity hub of the main acts on the hypothalamus, start and adjustment of erectile dysfunction. 1999-year clinical study reports, a group of 520 cases, double-blind test results indicate that the medication 2mg effective rate of 44 per cent of the group. 0% (placebo is 37. 8%), taking effective rate was 58 per cent of the 4mg group. 1% (placebo is 36. 6%), taking effective rate of 52 per cent of the 5mg group. 8% (placebo for 28. 9%). Medication effective rate of 60 per cent of the 6mg group. 9% (placebo is 29. 3%), the main side effects are nausea, vomiting, 2mg group is 0, respectively. 5%,4mg group is 11. 7%,5mg group was 16. 0%,6mg group was 16. 6%. Clinical studies are still made, has not yet been applied to clinical.

2 sildenafil (Sildenafil) is promoting drug around. It is acid-5-phosphate diester (PDE 5) inhibitor. Main role in the local and the peripheral nervous system, by inhibiting phosphodiesterase type 5, enhancing the role of nitric oxide, reducing degradation and promotion of the Ukrainian camp, Central or enhances erectile function. Has been used in clinical, oral dose of 25mg,50mg and 100mg, on-demand in an hour before sexual intercourse take. Europe and the United States drug groups efficient 70% of clinical study reports (777) in the placebo group 21% (441). 7 units of 614 cases of clinical study reports, total effective rate of 81%, (the placebo group for 40%). Its main manifestation of adverse reactions to: flushing (vasodilator), dizziness, headache, abnormal vision, nasal congestion. Peking Union Medical College Hospital of 93 cases of research results, total effective rate 81%, (placebo group for 35%). Adverse reactions: flushing (vasodilator), dizziness, headaches, eye irritation, heart palpitations, indigestion.

3 phentolamine (Phentolamine) is promoting drug around. It is Alpha-1 adrenergic receptor inhibitor, primarily through inhibition of epinephrine and norepinephrine, leading to smooth muscle relaxation, promote or enhance erectile function. At present, except for South America, Mexico, and Brazil national, to clinic, are still in the process of conducting clinical studies, oral effective rate of 40~60%. Major adverse reactions to nasal. Beijing and Shanghai in China and phentolamine on the production of China conducting multicenter clinical study of Tablet, oral dose of 40mg, on-demand to 30 minutes before sexual intercourse take.

Four dynamic, new drug research

Current United States are highly selective inhibition of phosphodiesterase type 5 new drugs. To reduce the adverse drug reaction of sildenafil as the goal, only inhibits PDE5 and not inhibit other PDE, especially does not inhibit PDE6. The compound operation codenamed IC351, has 44 cases of preliminary research has shown that, with improved erectile function.